Description: Rabbit polyclonal antibody to Nibrin (Phospho-S343) Immunogen: KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding S343 of human Nibrin protein. The exact sequence is proprietary. Purification: The antibody was purified by immunogen affinity chromatography. Clonality: Polyclonal Form: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. Dilution: WB (1/500 - 1/1000) Gene Symbol: NBN Alternative Names: NBS; NBS1; P95; Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1Entrez Gene (Human): 4683Entrez Gene (Mouse) : 27354Entrez Gene (Rat) : 85482SwissProt (Human): O60934SwissProt (Mouse) : Q9R207SwissProt (Rat) : Q9JIL9Storage/Stability : Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
-
Western blot analysis of Nibrin (Phospho-S343) expression in Jurkat (A), LO2 UV-treated (B), Raw264.7 UV-treated (C), PC12 (D) whole cell lysates.
Direct Activation of ATM by Resveratrol under Oxidizing Conditions
Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours
Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition
The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo