Description: Rabbit polyclonal antibody to GSK3 alpha/beta (Phospho-Y279/216) Immunogen: KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding Y279/216 of human GSK3 alpha/beta protein. The exact sequence is proprietary. Purification: The antibody was purified by immunogen affinity chromatography. Clonality: Polyclonal Form: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. Dilution: WB (1/500 - 1/1000), IH (1/100 - 1/200) Gene Symbol: GSK3A; GSK3B Alternative Names: GSK3A; Glycogen synthase kinase-3 alpha; GSK-3 alpha; Serine/threonine-protein kinase GSK3A; GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3BEntrez Gene (Human): 2931Entrez Gene (Mouse) : 606496; 56637Entrez Gene (Rat) : 50686; 84027SwissProt (Human): P49840; P49841SwissProt (Mouse) : Q2NL51; Q9WV60SwissProt (Rat) : P18265; P18266Storage/Stability : Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
-
Western blot analysis of GSK3 alpha/beta (Phospho-Y279/216) expression in mouse testis (A), rat testis (B), rat spleen (C) whole cell lysates.
-
Immunohistochemical analysis of GSK3 alpha/beta (Phospho-Y279/216) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer
The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of ß-catenin through mechanisms involving FRAT1 and PAK4
Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of ß-catenin
Exogenous Activation of Wnt/ß-Catenin Signaling Attenuates Binge Alcohol-Induced Deficient Bone Fracture Healing
CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation
Activity-dependent regulation of dendritic growth and maintenance by glycogen synthase kinase 3ß
Distinct expression and activity of GSK-3a and GSK-3ß in prostate cancer
Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B
Issues associated with the use of phosphospecific antibodies to localise active and inactive pools of GSK-3 in cells
Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells