Description: Rabbit polyclonal antibody to Beta-arrestin-1 Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Beta-arrestin-1. The exact sequence is proprietary. Purification: The antibody was purified by immunogen affinity chromatography. Clonality: Polyclonal Form: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. Dilution: WB (1/500 - 1/1000), IH (1/100 - 1/200) Gene Symbol: ARRB1 Alternative Names: ARR1; Beta-arrestin-1; Arrestin beta-1Entrez Gene (Human): 408Entrez Gene (Mouse) : 109689Entrez Gene (Rat) : 25387SwissProt (Human): P49407SwissProt (Mouse) : Q8BWG8SwissProt (Rat) : P29066Storage/Stability : Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
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Western blot analysis of Beta-arrestin-1 expression in MCF7 (A), mouse brain (B), H9C2 (C) whole cell lysates.
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Immunohistochemical analysis of Beta-arrestin-1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
The Protective Signaling of Metabotropic Glutamate Receptor 1 Is Mediated by Sustained, {beta}-Arrestin-1-dependent ERK Phosphorylation