Description: Rabbit polyclonal antibody to PKA C beta Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PKA C beta. The exact sequence is proprietary. Purification: The antibody was purified by immunogen affinity chromatography. Clonality: Polyclonal Form: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. Dilution: WB (1/500 - 1/1000), IH (1/100 - 1/200) Gene Symbol: PRKACB Alternative Names: cAMP-dependent protein kinase catalytic subunit beta; PKA C-betaEntrez Gene (Human): 5567Entrez Gene (Mouse) : 18749Entrez Gene (Rat) : 293508SwissProt (Human): P22694SwissProt (Mouse) : P68181SwissProt (Rat) : P68182Storage/Stability : Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
-
Western blot analysis of PKA C beta expression in K562 (A), A549 (B), C6 (C) whole cell lysates.
-
Immunohistochemical analysis of PKA C beta staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways