Description: Rabbit polyclonal antibody to Granzyme B/H Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Granzyme B/H. The exact sequence is proprietary. Purification: The antibody was purified by immunogen affinity chromatography. Clonality: Polyclonal Form: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. Dilution: WB (1/500 - 1/1000), IH (1/100 - 1/200) Gene Symbol: GZMB; GZMH Alternative Names: GZMB; CGL1; CSPB; CTLA1; GRB; Granzyme B; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E; GZMH; CGL2; CTSGL2; Granzyme H; CCP-X; Cathepsin G-like 2; CTSGL2; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C; CSP-CEntrez Gene (Human): 2999Entrez Gene (Mouse) : 14939Entrez Gene (Rat) : 100361468SwissProt (Human): P10144; P20718SwissProt (Mouse) : P04187SwissProt (Rat) : P18291Storage/Stability : Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
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Western blot analysis of Granzyme B/H expression in HEK293T (A), H1688 (B), mouse lung (C), mouse liver (D), rat lung (E), rat liver (F) whole cell lysates.
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Immunohistochemical analysis of Granzyme B/H staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
The functionalized human serine protease granzyme B/VEGF121 targets tumor vasculature and ablates tumor growth
Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemia in rat model