Description: Peptide to Orexin A, Human, Mouse, Rat, Bovine, Canine, Ovine, Porcine Form: Lyophilized powder Alternative Names: Hypocretin-1 (human, bovine, canine, mouse, ovine, porcine, rat)CAS Number : 205640-90-0Molecular Formula : C152H247N47O44S4Molecular Weight : 3565.14Purity : > 95%Chemical Structure : pGlu-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bridge Cys6-Cys12, Cys7-Cys14)Application : Orexin A (hypocretin-1) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of orexin A to rats stimulated food consumption in a dose-dependent manner. The effect persisted at 4 h after injection, as orexin A seems to be resistant to peptidases. Orexin A specifically binds a G protein-coupled receptor, OX₁R (IC₅₀ = 20 nM to displace 50 % of radiolabeled orexin A bound to this receptor). Orexin A produced in the amygdala induces wakefulness and plays a role in the induction of human emotions. Narcolepsy has been associated with orexin deficiency.Storage/Stability : Shipped at 4°C. Store at -20°C for one year.

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