Description: Peptide to Endothelin-1, Human Form: Lyophilized powder Alternative Names: ET-1 (human, bovine, dog, mouse, porcine, rat)CAS Number : 117399-94-7Molecular Formula : C109H159N25O32S5Molecular Weight : 2491.95Purity : > 95%Chemical Structure : H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bridge Cys1-Cys15, Cys3-Cys11)Application : Endothelin-1, a 21-amino acid peptide from vascular endothelial cells of different mammalian species, is one of the most potent vasoconstrictors. ET-1 exerts a wide variety of effects on both vascular and non-vascular (e.g. heart, lung, brain) tissues. Toxic peptides from a snake venom, the sarafotoxins, show structural and functional homology to ET-1. The role of ET-1 in clinical hypertension has been reviewed by Dhaun et al. and by Sreenivas and Oparil. ET-1 plays a central role in lung fibrosis.Storage/Stability : Shipped at 4°C. Store at -20°C for one year.

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