Datasheet
MSDSDescription：Rabbit polyclonal antibody to JAK2 (Phospho-Y570)Immunogen：KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding Y570 of human JAK2 protein. The exact sequence is proprietary.Purification：The antibody was purified by immunogen affinity chromatography.Clonality：PolyclonalForm：Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.Dilution：WB (1/500 - 1/1000), IH (1/50 - 1/100)Gene Symbol：JAK2Alternative Names：Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
Entrez Gene (Human)：
3717;
Entrez Gene (Mouse)：
16452;
Entrez Gene (Rat)：
24514;
SwissProt (Human)：
O60674;
SwissProt (Mouse)：
Q62120;
SwissProt (Rat)：
Q62689;
Storage/Stability：Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
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Western blot analysis of JAK2 (Phospho-Y570) expression in HeLa (A), TF1 (B), rat kidney (C) whole cell lysates. (Predicted band size: 130 kD; Observed band size: 125 kD) -
Immunohistochemical analysis of JAK2 (Phospho-Y570) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis